ABC Transporters: Biochemical, Cellular, and Molecular by John N. Abelson, Melvin I. Simon, Suresh V. Ambudkar,

By John N. Abelson, Melvin I. Simon, Suresh V. Ambudkar, Michael M. Gottesman

The significantly acclaimed laboratory common for greater than 40 years, Methods in Enzymology is likely one of the such a lot hugely revered guides within the box of biochemistry. due to the fact 1955, every one quantity has been eagerly awaited, usually consulted, and praised via researchers and reviewers alike. greater than 285 volumes were released (all of them nonetheless in print) and lots more and plenty of the cloth is appropriate even today-truly an important booklet for researchersin all fields of existence sciences.

Key Features
* Prokaryotic ABC Transporters
* Eukaryotic ABC Transporters
* Nonmammalian ABC delivery Systems
* Mammalian P-Glycoproteins
* Multidrug Resistance linked Protein
* Cystic Fibrosis Transmembrane Conductance Regulator
* Sulfonylurea Receptor
* Intracellular ABC Transporters

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Additional resources for ABC Transporters: Biochemical, Cellular, and Molecular Aspects

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Dean, L. I. Hor, H. A. Shuman, and H. Nikaido, Mol. Microbiol. 6, 2033 (1992). 7 j. A. Hall, J. L. Chen, and H. Nikaido, unpublished data (1995). s A. L. Davidson and H. Nikaido, J. Biol. Chem. 265, 4254 (1990). '~ S. V. Ambudkar and P. C. Maloney, Methods" Enzymol. 125, 558 (1986). 10 S. V. Ambudkar and P. C. Maloney, J. Biol. Chem. 261, 10079 (1986). u E. Racker, B. Violand, S. O'Neal, M. Alfonzo, and J. Telford, Arch. Biochem. Biophys. 198, 470 (1979). 22 PROKARYOTIC A B C TRANSPORTERS [2] for ATP hydrolysis to o c c u r .

The rnalF and rnalG genes encode very hydrophobic polypeptides 13,14 that contain eight and six t r a n s m e m b r a n e segments, respectively. ~5,16 In addition, each of these proteins contains a large periplasmic domain of unknown function. IS Indeed the family resemblance with the m e m b e r s of the prokaryotic and eukaryotic branches of the A B C transporter family lies within the MalK protein sequence, s This subunit anchors to the MalF and/or M a l G subunits 19'2° and is required for their stable insertion in the 10M.

Mimmack, M. P. Gallagher, S. C. Hyde, S. R. Pearce, I. R. Booth, and C. F. Higgins, Proc. Natl. Acad. Sci. USA 86, 8257 (1989). s2 M. Muir, L. Williams and T. Ferenci, J. BacterioL 163, 1237 (1985). ~3A. L. Davidson, S. S. Laghaeian, and D. E. Mannering, J. Biol. Chem. 271, 4858 (1996). 84j. p. Abrahams, A. G. W. Leslie, R. Luner, and J. E. Walker, Nature 370, 621 (1994). 18 PROKARYOTIC ABC TRANSPORTERS [11 of the possible presence of closed conformers among ligand-free MBP molecules. Interesting results were obtained when the A T P hydrolysis assay was performed by using proteoliposomes containing MBP-independent mutants of rnalF and m a l G .

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